Children's National

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162 matching studies

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Navigating Pregnancy and Parenthood With Lyme Disease Children's National Research Institute Lyme Disease Post Treatment Lyme Disease Chronic Lyme Disease Tick-Borne Infections Tick-Borne Diseases This is a mixed methods study exploring the experiences of pregnancy and parenting among participants with Lyme disease. Eligible participants will have been diagnosed with Lyme disease (LD), post-treatment Lyme disease syndrome (PTLDS), and/or chronic Lyme (CL) either during or before a prior preg1 expand This is a mixed methods study exploring the experiences of pregnancy and parenting among participants with Lyme disease. Eligible participants will have been diagnosed with Lyme disease (LD), post-treatment Lyme disease syndrome (PTLDS), and/or chronic Lyme (CL) either during or before a prior pregnancy. Participants will complete quantitative surveys on topics such as their medical history, their child(ren)'s development, and demographic information. They will then participate in a qualitative interview where they will be asked about their experiences with pregnancy and with parenting their child(ren) in the context of their condition. Type: Observational Start Date: Mar 2024 open study
Randomized Study in Children and Adolescents With Migraine: Acute Treatment Pfizer Pediatric Migraine The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents. expand The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents. Type: Interventional Start Date: Jan 2021 open study
Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure Children's National Research Institute Lyme Disease Post-Treatment Lyme Disease Chronic Lyme Disease Tick-Borne Infections Pregnancy Complications The purpose of this pilot study is to assess the feasibility of longitudinal neurodevelopmental evaluation of fetuses and infants exposed to Lyme disease in utero. Participants with Lyme disease or Post-Treatment Lyme Disease Syndrome (PTLDS) will be recruited during pregnancy. Pregnancies will be1 expand The purpose of this pilot study is to assess the feasibility of longitudinal neurodevelopmental evaluation of fetuses and infants exposed to Lyme disease in utero. Participants with Lyme disease or Post-Treatment Lyme Disease Syndrome (PTLDS) will be recruited during pregnancy. Pregnancies will be monitored and infant development will be assessed from birth until age 18 months. Type: Observational Start Date: Jul 2023 open study
A Study to See Iftolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Th1 Otsuka Pharmaceutical Development & Commercialization, Inc. Autosomal Recessive Polycystic Kidney (ARPKD) To evaluate the safety of tolvaptan in pediatric subjects with ARPKD expand To evaluate the safety of tolvaptan in pediatric subjects with ARPKD Type: Interventional Start Date: Jan 2023 open study
Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Obesity Type 2 Diabetes Background: Type 2 diabetes is a disease that affects blood sugar levels. Complications can include heart and blood vessel (vascular) diseases. Rates of type 2 diabetes have tripled in children and young adults over the last 40 years. Vascular diseases are also increasing in young people. Objecti1 expand Background: Type 2 diabetes is a disease that affects blood sugar levels. Complications can include heart and blood vessel (vascular) diseases. Rates of type 2 diabetes have tripled in children and young adults over the last 40 years. Vascular diseases are also increasing in young people. Objective: To learn more about factors, including type 2 diabetes, that may cause vascular disease in young people. Eligibility: People aged 12 to 25 years who (1) have type 2 diabetes; (2) are overweight but not diabetic; (3) or are lean and healthy. Biological parents are also needed. Design: Young participants will visit the NIH clinic once a year for up to 25 years. Each visit will take 4 days. Before each visit, participants will wear devices to track their sleep, activity, and blood sugar levels for 7 to 10 days. At each visit, participants will have tests including: Samples: They will provide blood, urine, and stool samples. Heart: They will ride a stationary bike for 6 minutes with stickers applied to their chest. Scans: They will lie on a bed that slides into a tube; the machine will take pictures of the inside of their body. Energy: They will wear a hood over their head to measure the air they breathe. Social stress: They will give a speech for 10 minutes to show their body s response to stress. Glucose: They will drink a sweet drink to see how their blood sugar changes. Biological parents will have 1 study visit. They will have blood tests. They will fill in questionnaires about their lifestyle and stress. ... Type: Observational Start Date: Mar 2025 open study