The iCat2, GAIN (Genomic Assessment Informs Novel Therapy) Consortium Study


This research study is evaluating the use of specialized testing of solid tumors including sequencing. The process of performing these specialized tests is called tumor profiling. The tumor profiling may result in identifying changes in genes of the tumor that indicate that a particular therapy may have activity. This is called an individualized cancer therapy (iCat) recommendation. The results of the tumor profiling and, if applicable, the iCat recommendation will be returned.


  • Pediatric Solid Tumor


Eligible Ages
Under 30 Years
Eligible Genders
Accepts Healthy Volunteers

Inclusion Criteria

  • Age -- Age ≤ 30 years at time of initial qualifying solid tumor diagnosis
  • Diagnosis -- Histologic diagnosis of solid malignancy (excluding brain tumors and lymphoma) that meets at least one of the following criteria:
  • Refractory, defined as tumor progression after initiation of standard first line therapy without having achieved a prior partial or complete remission OR Biopsy proven residual disease at the completion of planned standard initial front-line therapy.
  • Recurrent, defined as tumor progression after achieving a prior partial or complete remission
  • Newly diagnosed high risk disease, defined as having an expected event free survival of < 50% at 2 years.
  • Lacks definitive diagnosis or classical genomic findings after histologic review and standard molecular testing (rare tumor group).
  • Examples include (eligibility not limited to these examples):
  • Histology typically associated with a fusion in which fusion is not detected.
  • Ewing-like sarcoma
  • Undifferentiated sarcoma
  • Inflammatory myofibroblastic tumor without ALK fusion
  • Infantile fibrosarcoma without NTRK fusion
  • Specimen Samples
  • Sufficient tumor specimen available to meet the minimum requirements for profiling from diagnosis or progression / recurrence
  • -- OR
  • Surgery / biopsy planned as part of clinical care that is anticipated to yield sufficient material to meet the minimum requirements for profiling; OR
  • Patient has already had molecular profiling and patient has not yet started matched targeted therapy based on the report .

Exclusion Criteria

  • No Therapy Planned
  • - Patients who have declined further anticancer therapy will be excluded.
  • Performance Status
  • - Patients with Lansky (age < 16 years) or Karnofsky (age ≥16 years) score < 50 will be excluded.
  • Life Expectancy -- Patients with anticipated life expectancy < 3 months will be excluded.

Study Design

Study Type
Intervention Model
Single Group Assignment
Primary Purpose
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Genetic testing and GAIN report
All enrolled patients will submit specimens for sequencing and analysis.
  • Genetic: Genetic testing and GAIN report
    All patients enrolled will submit specimens for genetic analysis. If successful the report will be reviewed to look for possible recommendations and a GAIN report will be generated regardless of possible recommendations.

Recruiting Locations

Children's National and nearby locations

Children's National Medical Center
Washington, District of Columbia 20010
AeRang Kim, MD,PhD

More Details

Dana-Farber Cancer Institute

Study Contact

Katherine Janeway, MD

Detailed Description

Patients with extra-cranial (not in the brain) solid tumors that are either difficult to diagnose or more difficult to treat are eligible to participate in this study. All enrolled patients will have targeted sequencing of tumor performed. Sequencing results will be reviewed for clinically significant findings including determination of whether any mutations exist that suggest potential for activity of a targeted therapy (iCat recommendation). Results will be returned to the patient's oncologist and follow-up data will be collected.

In this prospective multi-center cohort study, the primary objective is to describe the outcomes of pediatric patients with advanced solid tumors according to whether or not they received of targeted therapy matched to an iCat recommendation. The primary clinical outcome of interest is the endpoint of overall survival (OS), with progression-free survival and response rate (RR) as key secondary clinical outcome measures. To address this hypothesis, 825 patients will enroll from an anticipated 11 participating institutions over 3 years.