Central Blood Pressure and Pulse Wave Velocity in Kidney Transplant Recipients

Purpose

An observational cohort study will be conducted to non-invasively investigate central blood pressure and pulse wave velocity in children with kidney disease and controls. Using an oscillometric monitor, the investigators aim to non-invasively obtain the central blood pressure and pulse wave velocity (PWV), or arterial stiffness, of children with kidney disease. The investigators will also enroll age- and race-matched healthy controls and measure the same parameters for comparison. In addition, the investigators will measure PWV by standard arterial tonometry method in a subset of patients.

Condition

  • End Stage Renal Disease

Eligibility

Eligible Ages
Between 3 Years and 21 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • kidney transplant recipients who are at least 6 months post-transplant - healthy children matched for age sex and race

Exclusion Criteria

  • age less than 3 years

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
children with kidney disease Kidney transplant recipients age 3 to 21 years
  • Other: there is no intervention
    There is no intervention in this study. It is observational only.
healthy control Healthy children age 3 to 21 years
  • Other: there is no intervention
    There is no intervention in this study. It is observational only.

Recruiting Locations

Children's National and nearby locations

Children's National Medical Cetner
Washington, District of Columbia 20010
Contact:
Asha Moudgil, MD
amoudgil@cnmc.org

More Details

NCT ID
NCT04212143
Status
Recruiting
Sponsor
Children's National Research Institute

Study Contact

Kristen Sgambat, PhD
202-476-5058
ksgambat@childrensnational.org

Detailed Description

The specific aims of the study are as follows: 1. Using an oscillometric blood pressure monitor, the investigators aim to non-invasively obtain the central blood pressure and pulse wave velocity (PWV), or arterial stiffness, of children with kidney disease. 2. Measure oscillometric central blood pressure and PWV in age and race matched healthy children. 3. Measure PWV by standard arterial tonometry method in a subset of patients, and compare these measurements to the PWV measured using the oscillometric device. 4. Measure body composition of patients and controls (Body Mass Index, Waist-to-Height ratio, %body fat, and mid-arm muscle circumference) to see how this relates to central blood pressure and PWV.