Neonatal Seizure Registry - Developmental Functional EValuation
Purpose
The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for developmental disabilities and whether these are modified by parent well-being.
Conditions
- Neonatal Seizure
- Hypoxic-Ischemic Encephalopathy
- Stroke
- Intracranial Hemorrhages
- Epilepsy
- Cerebral Palsy
- Intellectual Disability
Eligibility
- Eligible Ages
- Between 2 Years and 8 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Enrolled in NSR-II - Alive at the start of the NSR-DEV study period - Parent(s) who are English or Spanish literate (with assistance of interpreter)
Exclusion Criteria
- Neonates who were found to have exclusion criteria after NSR-II enrollment - Risk for adverse outcome independent of seizures and underlying brain injury (including but not limited to: inborn errors of metabolism, fetal infection, brain malformation) - Transient cause for seizures (e.g., mild hypoglycemia, hyponatremia, hypocalcemia with normal neuroimaging) - Neonatal-onset epilepsy syndromes
Study Design
- Phase
- Study Type
- Observational [Patient Registry]
- Observational Model
- Cohort
- Time Perspective
- Prospective
Recruiting Locations
Children's National and nearby locations
Washington, District of Columbia 20010
More Details
- NCT ID
- NCT04337697
- Status
- Recruiting
- Sponsor
- University of California, San Francisco
Detailed Description
Neonatal seizures due to brain injury (acute symptomatic seizures) are associated with high risk of neurodevelopmental disability in infancy. Although prognosis in early childhood is a critical question for parents and providers, outcomes beyond infancy are largely unknown. Further, parents of infants with neonatal seizures are at risk for mental health disorders, which can undermine their ability to care for a child with medical complexity and may contribute to impaired child development. The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants enrolled at one of nine sites across the USA. Participants will be evaluated using developmental questionnaires and in-person neurodevelopmental testing. Parent well-being will be assessed at each time point.